Transforming Growth Factor-β1, Transforming Growth Factor-β2, and Transforming Growth Factor-β3 Enhance Ovarian Cancer Metastatic Potential by Inducing a Smad3-Dependent Epithelial-to-Mesenchymal Transition
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منابع مشابه
Transforming Growth Factor-B1, Transforming Growth Factor-B2, and Transforming Growth Factor-B3 Enhance Ovarian Cancer Metastatic Potential by Inducing a Smad3-Dependent Epithelial-to-Mesenchymal Transition
Transforming growth factor-B (TGF-B) is thought to play a role in the pathobiological progression of ovarian cancer because this peptide hormone is overexpressed in cancer tissue, plasma, and peritoneal fluid. In the current study, we investigated the role of the TGF-B/ Smad3 pathway in ovarian cancer metastasis by regulation of an epithelial-to-mesenchymal transition. When cancer cells were cu...
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ژورنال
عنوان ژورنال: Molecular Cancer Research
سال: 2008
ISSN: 1541-7786,1557-3125
DOI: 10.1158/1541-7786.mcr-07-0294